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Research Article

Research Article Antigenotoxic Effects of Biochaga and Dihydroquercetin (Taxifolin) on H2O2-Induced DNA Damage in Human Whole Blood Cells

Lada Živković ,1 Vladan Bajić,2 Dijana Topalović ,1 Marija Bruić,1 and Biljana Spremo-Potparević 1 1Center for Biological Research, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia 2LaboratoryforRadiobiologyandMolecularGenetics,InstituteforNuclearResearch “Vinča”,UniversityofBelgrade,MikePetrovića Alasa 12-14, 11000 Belgrade, Serbia Correspondence should be addressed to Lada Živković; Received 9 July 2019; Revised 30 September 2019; Accepted 5 October 2019; Published 11 November 2019

Academic Editor: Vladimir Jakovljevic Copyright © 2019 LadaŽivkovićet al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The health benefits of natural products have long been recognized. Consumption of dietary compounds such as supplements provides an alternative source of natural products to those obtained from the diet. There is a growing concern regarding the possible side effects of using different food supplements simultaneously, since their possible interactions are less known. For the first time, we have tested genotoxic and antigenotoxic effects of Biochaga, in combination with dihydroquercetin. No genotoxic effect on whole blood cells was observed within individual treatment of Biochaga (250μg/mL, 500μg/mL and 1000μg/mL) and dihydroquercetin (100μg/mL, 250μg/mL and 500μg/mL), nor in combination. Afterwards, antigenotoxic potency of both supplements against hydrogen peroxide- (H2O2-) induced DNA damage to whole blood cells (WBC) was assessed, using the comet assay. Biochaga and dihydroquercetin displayed a strong potential to attenuate H2O2-induced damage on DNA in cells at all tested concentrations, with a statistical significance (p



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